Speciation and behaviour of free Fe III haem in aqueous solution. Interaction of Fe III haem with antimalarials and effects on haem in cultured parasites. His main research interests are in the therapeutic aspects of HIV-associated tuberculosis and drug-resistant tuberculosis, antiretroviral therapy in resource-limited settings, and the pharmacokinetics of antiretroviral and anti-tuberculosis drugs.
She participates in research projects across Africa, as well as in Asia and South America where a key interest is the support and mentoring of investigator-initiated pharmacology research projects. Computational scientist with expertise in the development of Parallel and Hybrid model computer codes for application to chemical, life and biomedical sciences.
Research is balanced between development of life science software and its application to biomedical projects where more recently the biomedical application has been cancer. Scientific interests are focused on the roles that carbohydrates play in biological processes. A demonstration of the application of computational expertise is his use of molecular modelling simulations to develop therapeutics for cancer as well as his use of data analytics and informatics methods to develop diagnostics and prognostics for cancer.
Research focuses on the molecular genetic changes in oesophageal cancer using a whole genome sequencing approach to identify mutation signatures, epigenetic changes, gene mutation, deletions and insertions with specific relevance to early diagnosis and targeted therapeutic interventions in cancer.
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